Central role of VDR conformations for understanding selective actions of vitamin D3 analogues
Identifieur interne : 000A31 ( Main/Exploration ); précédent : 000A30; suivant : 000A32Central role of VDR conformations for understanding selective actions of vitamin D3 analogues
Auteurs : Carsten Carlberg [Allemagne] ; Marcus Quack [Allemagne] ; Michaela Herdick [Allemagne] ; Yvonne Bury [Allemagne] ; Patsie Polly [Allemagne] ; Andrea Toell [Allemagne]Source :
- Steroids [ 0039-128X ] ; 2001.
English descriptors
- KwdEn :
Abstract
The vitamin D3 receptor (VDR) acts primarily as a heterodimer with the retinoid X receptor (RXR) on different types of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) response elements (VDREs). Therefore, DNA-bound VDR-RXR heterodimers can be considered as the molecular switches of 1α,25(OH)2D3 signalling. Functional conformations of the VDR within these molecular switches appear to be of central importance for describing the biologic actions of 1α,25(OH)2D3 and its analogues. Moreover, VDR conformations provide a molecular basis for understanding the potential selective profile of VDR agonists, which is critical for a therapeutic application. This review discusses VDR conformations and their selective stabilization by 1α,25(OH)2D3 and its analogues, such as EB1089 and Gemini, as a monomer in solution or as a heterodimer with RXR bound to different VDREs and complexed with coactivator or corepressor proteins.
Url:
DOI: 10.1016/S0039-128X(00)00150-1
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Central role of VDR conformations for understanding selective actions of vitamin D3 analogues</title><author><name sortKey="Carlberg, Carsten" sort="Carlberg, Carsten" uniqKey="Carlberg C" first="Carsten" last="Carlberg">Carsten Carlberg</name></author><author><name sortKey="Quack, Marcus" sort="Quack, Marcus" uniqKey="Quack M" first="Marcus" last="Quack">Marcus Quack</name></author><author><name sortKey="Herdick, Michaela" sort="Herdick, Michaela" uniqKey="Herdick M" first="Michaela" last="Herdick">Michaela Herdick</name></author><author><name sortKey="Bury, Yvonne" sort="Bury, Yvonne" uniqKey="Bury Y" first="Yvonne" last="Bury">Yvonne Bury</name></author><author><name sortKey="Polly, Patsie" sort="Polly, Patsie" uniqKey="Polly P" first="Patsie" last="Polly">Patsie Polly</name></author><author><name sortKey="Toell, Andrea" sort="Toell, Andrea" uniqKey="Toell A" first="Andrea" last="Toell">Andrea Toell</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BF594BD05AF28D39293AB85B9ABB003FA478187E</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1016/S0039-128X(00)00150-1</idno><idno type="url">https://api.istex.fr/document/BF594BD05AF28D39293AB85B9ABB003FA478187E/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000876</idno><idno type="wicri:Area/Main/Curation">000870</idno><idno type="wicri:Area/Main/Exploration">000A31</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Exploration">000A31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Central role of VDR conformations for understanding selective actions of vitamin D3 analogues</title><author><name sortKey="Carlberg, Carsten" sort="Carlberg, Carsten" uniqKey="Carlberg C" first="Carsten" last="Carlberg">Carsten Carlberg</name><affiliation wicri:level="1"><country wicri:rule="url">Allemagne</country></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Physiologische Chemie I, Heinrich-Heine-Universität, Postfach 10 10 07, D-40001 Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Quack, Marcus" sort="Quack, Marcus" uniqKey="Quack M" first="Marcus" last="Quack">Marcus Quack</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Physiologische Chemie I, Heinrich-Heine-Universität, Postfach 10 10 07, D-40001 Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Herdick, Michaela" sort="Herdick, Michaela" uniqKey="Herdick M" first="Michaela" last="Herdick">Michaela Herdick</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Physiologische Chemie I, Heinrich-Heine-Universität, Postfach 10 10 07, D-40001 Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Bury, Yvonne" sort="Bury, Yvonne" uniqKey="Bury Y" first="Yvonne" last="Bury">Yvonne Bury</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Physiologische Chemie I, Heinrich-Heine-Universität, Postfach 10 10 07, D-40001 Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Polly, Patsie" sort="Polly, Patsie" uniqKey="Polly P" first="Patsie" last="Polly">Patsie Polly</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Physiologische Chemie I, Heinrich-Heine-Universität, Postfach 10 10 07, D-40001 Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Toell, Andrea" sort="Toell, Andrea" uniqKey="Toell A" first="Andrea" last="Toell">Andrea Toell</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Physiologische Chemie I, Heinrich-Heine-Universität, Postfach 10 10 07, D-40001 Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Steroids</title><title level="j" type="abbrev">STE</title><idno type="ISSN">0039-128X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">66</biblScope><biblScope unit="issue">3–5</biblScope><biblScope unit="page" from="213">213</biblScope><biblScope unit="page" to="221">221</biblScope></imprint><idno type="ISSN">0039-128X</idno></series><idno type="istex">BF594BD05AF28D39293AB85B9ABB003FA478187E</idno><idno type="DOI">10.1016/S0039-128X(00)00150-1</idno><idno type="PII">S0039-128X(00)00150-1</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0039-128X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coactivators</term><term>Corepressors</term><term>Gel shift clipping assay</term><term>Limited protease digestion assay</term><term>Nuclear receptor conformations</term><term>Promoter selectivity</term><term>Protein-DNA interaction</term><term>Vitamin D</term><term>Vitamin D receptor agonists</term><term>Vitamin D signalling pathways</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The vitamin D3 receptor (VDR) acts primarily as a heterodimer with the retinoid X receptor (RXR) on different types of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) response elements (VDREs). Therefore, DNA-bound VDR-RXR heterodimers can be considered as the molecular switches of 1α,25(OH)2D3 signalling. Functional conformations of the VDR within these molecular switches appear to be of central importance for describing the biologic actions of 1α,25(OH)2D3 and its analogues. Moreover, VDR conformations provide a molecular basis for understanding the potential selective profile of VDR agonists, which is critical for a therapeutic application. This review discusses VDR conformations and their selective stabilization by 1α,25(OH)2D3 and its analogues, such as EB1089 and Gemini, as a monomer in solution or as a heterodimer with RXR bound to different VDREs and complexed with coactivator or corepressor proteins.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Düsseldorf</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Düsseldorf</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Carlberg, Carsten" sort="Carlberg, Carsten" uniqKey="Carlberg C" first="Carsten" last="Carlberg">Carsten Carlberg</name></noRegion><name sortKey="Bury, Yvonne" sort="Bury, Yvonne" uniqKey="Bury Y" first="Yvonne" last="Bury">Yvonne Bury</name><name sortKey="Carlberg, Carsten" sort="Carlberg, Carsten" uniqKey="Carlberg C" first="Carsten" last="Carlberg">Carsten Carlberg</name><name sortKey="Herdick, Michaela" sort="Herdick, Michaela" uniqKey="Herdick M" first="Michaela" last="Herdick">Michaela Herdick</name><name sortKey="Polly, Patsie" sort="Polly, Patsie" uniqKey="Polly P" first="Patsie" last="Polly">Patsie Polly</name><name sortKey="Quack, Marcus" sort="Quack, Marcus" uniqKey="Quack M" first="Marcus" last="Quack">Marcus Quack</name><name sortKey="Toell, Andrea" sort="Toell, Andrea" uniqKey="Toell A" first="Andrea" last="Toell">Andrea Toell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/explor/SchutzV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A31 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A31 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Musique
|area= SchutzV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:BF594BD05AF28D39293AB85B9ABB003FA478187E
|texte= Central role of VDR conformations for understanding selective actions of vitamin D3 analogues
}}
| This area was generated with Dilib version V0.6.38. |  |